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NAD+ Precision Protocol Wholesale Bottle

NAD+

Nicotinamide Adenine Dinucleotide

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme in all living cells, essential for metabolic processes and cellular function. It acts as a mediator of redox reactions, alternating between its oxidized (NAD+) and reduced (NADH) forms to facilitate electron transfer, crucial for energy production and sustaining life. Involved in over 500 enzymatic reactions, NAD+ is central to maintaining cellular homeostasis. Research shows that NAD+ may be beneficial in improving muscle function, protecting cells of the nervous system, and generally reducing the effects of aging.

Beyond energy metabolism, NAD+ supports DNA repair and gene regulation through enzymes like sirtuins and PARPs. Sirtuins use NAD+ to regulate cellular functions such as DNA repair, gene expression, and aging, while PARPs utilize it to repair DNA damage and maintain genomic stability. These roles underscore NAD+’s importance in cellular integrity and combating aging.

 

This product is intended as a research chemical only. Not for human use. Peptides will arrive in a lyophilized (powder) form for maximum stability.

NAD+, short for nicotinamide adenine dinucleotide, is the oxidized form of NADH. It’s main biological function is to carry electrons from one biochemical reaction to another, acting to shuttle energy within a cell and, in certain conditions, to extracellular locations as well. NAD+ also plays roles in enzyme activation/deactivation, posttranslational modification of proteins, and cell-to-cell communication. As an extracellular signaling molecule, NAD+ has been found to be released from neurons in blood vessels, the bladder, the large intestine, and from certain neurons in the brain.

Sequence: N/A
Molecular Formula: C21H27N7O14P2
Molecular Weight: 663.43 g/mol
PubChem CID: 925
CAS Number: 53-84-9
Synonyms: nicotinamide adenine dinucleotide, beta-NAD, NAD, Endopride

  • NAD+ is best thought of as a support molecule that is essential to cellular metabolism as well as extracellular communication. Research shows that NAD+ plays important roles in energy conversion, DNA repair, immune defense, and circadian cycles. Levels of the cofactor, however, are sensitive to disease state as well as age. NAD+ as the following effects that decline as a result of natural age-related decreases in the levels of the cofactor.
  • NAD+ activates sirtuins and other enzymes, liked Poly-ADP-ribose polymerases, involved in DNA repair and inflammatory processes. Sirtuins are the same enzymes linked to the life-extending benefits of calorie restriction.
  • NAD+ controls the production of the protein PGC-1-alpha, which protects neurons and other cells in the central nervous system from oxidative stress. Research in mice shows that this particular effect may be linked to improved memory, particularly with aging.
  • In mouse models, NAD+ helps to protect blood vessels against age-related hardening and the deposition of atherosclerotic plaques. In some studies, the cofactor even helps to reverse age-related dysfunction of the aorta.
  • Mice given NAD+ show increased rates of metabolism and improved lean body mass.
  • Increased NAD+ levels can increase muscle strength and endurance in older mice.
  • NAD+ has been linked to extracellular signaling, particularly for smooth muscle. It may be of benefit in GI function. This effect is likely responsible for NAD+ benefits on blood pressure.

Storage Instructions:

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.

Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.

For further information on proper storage techniques, click the link below:

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